TESCAN in cooperation with Masarik Cancer Research Lab work on the optimisation of the multimodal holographic microscope, Q-PHASE. Such efforts have also led to the development of new applications of this microscope in cell biology. Our primary focus is on cell biology and also on metabolism and biology of cancer cells. A significant goal of this research is finding some connections between cellular processes and changes in cell morphology.
Quantitative phase image can provide information on sample morphology, topography or cell dry mass distribution. The fluorescent module enables confirmation of observed processes by detection of well-known morphological features. In combination with the fluorescent mode, Q-PHASE has the capability to reliably identify different types of cell death, cell-cell interactions, cell cycle phase, cell division as well as other various cellular processes.
Q-PHASE provides a very simple and sensitive tool for monitoring of treatment responses at a cell level. Analyses of cell movement, growth or various other parameters are also possible. In combination with classical molecular and biochemical analyses, Q-PHASE provides a comprehensive view of cell behaviour. The generated records (and data) constitute valuable material suitable for publication as well as teaching.
- MASARIK CANCER RESEARCH LAB
- Oxidative Stress Resistance in Metastatic Prostate Cancer: Renewal by Self-Eating
- Multimodal Holographic Microscopy: Distinction between Apoptosis and Oncosis
- Coherence-controlled holographic microscopy principle embodiment into Q-PHASE microscope: story of a successful technology transfer